NAD+ powers the reactions that turn food into usable energy, and it supports the enzymes that maintain and repair your cells every day. In a 2022 community study of 1,518 adults, men had a higher average whole-blood NAD+ than women (about 34.5 versus 31.3 micromoles per liter), and they were also the group that showed a significant decline with age.
That drop was most pronounced among men aged 60 and older, while the broader downward trend began earlier, with the overall population showing a significant dip in the 40-49 age group. If you're looking into NAD for men over 40, that makes your 40s a smart window to start building supportive habits.
Our guide to NAD after 40 covers how these shifts show up in everyday energy, skin, and focus, and why supporting the whole NAD+ pathway matters more than chasing a big number on a label.
NAD+ isn't a fixed resource. Your body makes, uses, and recycles it every day, so daily habits and consistent supplementation help keep your supply steady through every decade.* That's what keeps your cells well-resourced for the work, workouts, and weekends you care about most, through your 40s, 50s, 60s, and beyond.
Best NAD supplement for men: our two favorites
We built two pouches that support NAD+ in different ways, so you can choose a focused pathway formula, a broader daily foundation, or both.
NAD+ Complete: direct NAD+ plus NMN*
NAD+ Complete delivers 50mg of direct liposomal NAD+ for immediate support alongside 400mg of NMN. In a randomized, double-blind, placebo-controlled study of healthy adults ages 40 to 65, a clinically-studied dose of NMN significantly increased blood NAD+ levels at both 30 and 60 days, and our 400mg dose falls within that effective range.† Because NMN conversion draws on your body's limited methyl groups, we include 500mg of TMG and 300mcg of B12 as methylcobalamin to keep that cycle running efficiently.* Methylcobalamin is the most bioavailable form of B12, and it also supports energy and mental clarity.* Our advanced waterless liposomal system, made with organic coconut-derived MCT oil and avocado oil, protects NAD+ through digestion so more of it reaches your cells.* Each single-serve pouch holds one full daily serving, with no pills to count or powders to mix. It's vegetarian (it contains honey), so check the full ingredient list on the product page for allergens and sensitivities.
Longevity: total-body recovery support*
Longevity is designed for high-energy humans who want foundational support after travel, workouts, or busy weeks. It combines 100mg of liposomal glutathione for detox and liver support, 100mg of CoQ10 (Ubiquinol™) for heart and mitochondrial health, 75mg of vegan lactoferrin, 2,000mcg of methylated B12, 600mg of MCT, and 15mg of NAD+.* Our patented lactoferrin delivery binds NAD+ and glutathione to help them pass through the gut lining.* Glutathione is often called the body's master antioxidant, and CoQ10 supports heart health and mitochondrial function.* Take it each morning. It's well absorbed with or without food, with best results on an empty stomach. It's vegan and gluten-free, and it contains tree nuts (almonds).
NAD benefits for men*
The advantages of steady NAD+ show up where men notice them first: in daily energy and in how well the body recovers after effort.
Steadier energy and focus*
Your mitochondria rely on NAD+ to carry electrons through the reactions that produce ATP, the fuel behind every movement and thought. Your brain runs on the same energy, and NAD+ supports the brain's energy metabolism that fuels mental clarity and focus, right through long meetings and demanding afternoons.* Our post on the benefits of NAD+ covers the many roles this coenzyme plays across your body. With consistent support, energy feels smoother and more reliable rather than arriving in caffeine-fueled bursts.* NAD+ also supports a healthy metabolism, helping your body turn meals into usable fuel more efficiently.*
Recovery and muscle health*
NAD+ fuels PARPs, enzymes that help repair DNA, and sirtuins, which help regulate how cells respond to stress, including the stress of hard training.* Muscle research offers a useful clue. In a 2022 Nature Aging study, older adults who exercised regularly had muscle NAD+ levels close to those of young adults, and daily step counts correlated with muscle NAD+ abundance. The study captured one moment in time, so it can't show cause and effect, but it points to movement as a smart habit. Pair it with daily NAD+ support, and your muscles get steady resources for recovery.* Strength and mobility are what keep you doing the things you love, which is why steady habits are worth building early.
Smart habits for your NAD routine
Supplements work best inside a routine that respects how your body makes and uses NAD+.
- Mind your dose: The number on the label isn't the number your cells receive. That's why NAD+ Complete pairs 50mg of protected, direct NAD+ with 400mg of NMN instead of chasing a bigger number. Our guide to daily NAD+ dosing explains why delivery matters as much as the milligrams.*
- Skip the hype: If an NAD testosterone claim sounds too good to be true, it probably is. Look for brands that stick to what the research shows and name the studies behind their claims, the way we do with NMN.
- Protect your sleep: Cellular repair is most active overnight, so consistent, restful sleep helps your body make good use of NAD+.*
- Plan for nights out: Your body uses NAD+ to process alcohol, drawing on the same supply your cells rely on for energy. Pace yourself, hydrate, and keep your daily pouch on schedule.
- Anchor the habit: Tie your daily pouch to an existing ritual like brewing coffee, so consistent support becomes automatic.
- Check lab results: Choose formulas with published third-party testing for purity, potency, heavy metals, and harmful bacteria before you buy.
Small, steady choices like these turn a good supplement into a routine that serves you for decades.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Clinical reference: Yi L, et al. GeroScience. 2022. Study conducted on NMN as a standalone ingredient.
Sources:
- Yi, L., Maier, A. B., Tao, R., Lin, Z., Vaidya, A., Pendse, S., Thasma, S., Andhalkar, N., Avhad, G., & Kumbhar, V. (2022). The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience, 45(1). https://doi.org/10.1007/s11357-022-00705-1
- Yang F, Deng X, Yu Y, Luo L, Chen X, Zheng J, Qiu Y, Xiao F, Xie X, Zhao Y, Guo J, Hu F, Zhang X, Ju Z, Zhou Y. Association of Human Whole Blood NAD+ Contents With Aging. Front Endocrinol (Lausanne). 2022 Mar 21;13:829658. doi: 10.3389/fendo.2022.829658. PMID: 35388296; PMCID: PMC8979162. https://pmc.ncbi.nlm.nih.gov/articles/PMC8979162/
- Janssens GE, Grevendonk L, Perez RZ, Schomakers BV, de Vogel-van den Bosch J, Geurts JMW, van Weeghel M, Schrauwen P, Houtkooper RH, Hoeks J. Healthy aging and muscle function are positively associated with NAD+ abundance in humans. Nature Aging. 2022.
